Pain & Inflammation
Most impactful studies listed first — prioritizing recent mechanistic work (e.g., inflammasome and ion-channel inhibition) and authoritative reviews on L-THP/Corydalis analgesia.
Figure 1 — Pain & Inflammation
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Stress & Anxiety
Preclinical work suggests L-THP reduces stress-induced behaviors and anxiety-like phenotypes, with studies spanning PTSD-like models and dopaminergic/GABAergic modulation.
Figure 1 — Stress & Anxiety
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Sleep & Restoration
Rodent EEG work indicates L-THP increases NREM sleep and reduces wakefulness, with hypnotic effects linked to D1/D2 receptor pathways in neuropathic pain models.
Figure 1 — Sleep & Restoration
Addiction & Recovery
Across cocaine, opioids, ethanol and nicotine models, L-THP consistently reduces self-administration and reinstatement; mechanisms include dopaminergic (D2/D3) antagonism and related circuit modulation.
Figure 1 — Addiction & Recovery
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